Which of the following differentiates ulcerative colitis from Crohn’s disease.. Crohn’s disease has primarily mucosal involvement and it is transmural with ulcerative colitis

Which of the following differentiates ulcerative colitis from Crohn’s disease?
A- Crohn’s disease primarily affects the left colon and rectum and ulcerative colitis most often affects the right colon and distal ileum.
B- Crohn’s disease presents with shallow ulcerations and ulcerative colitis presents with a cobblestone appearance of the mucosal lining.
C- The extent of involvement is noncontiguous and segmented with Crohn’s disease and it is contiguous and diffuse with ulcerative colitis.
D- Crohn’s disease has primarily mucosal involvement and it is transmural with ulcerative colitis.

Correct Response: C

The extent of involvement is noncontiguous and segmented with Crohn’s disease; and it is contiguous and diffuse with ulcerative colitis. Other differentiating characteristics include:
The typical area of intestinal involvement is the left colon and rectum for ulcerative colitis and the right colon and distal ileum with Crohn’s disease.
The mucosal appearance has a cobblestone appearance with granulomas with Crohn’s disease; and it appears edematous with shallow ulcerations and superficial bleeding.
The inflammation associated with Crohn’s disease is transmural, and it is mostly mucosal among those with ulcerative colitis.