Treatment of non-respondable cases of prednisolone:
Adult unresponsive cases of systemic steroids may be treated with the following drugs:
Immuno-suppressive drugs:
Immunosuppressive agents may be used in adult patients who do not respond to corticosteroids but their use should be given to elective conditions. Immunosuppressants are not given to young patients with SLE.
- Azithoprene does not add anything to high doses of steroids in mild and moderate renal conditions, sudden withdrawal may cause relapse.
Cyclophosphamide may be more effective than immunosuppressive but more toxic than azathioprine.
Triad therapy: Prednisone azathyoprine and cyclophosphamide have no preference for treatment with prednisolone and azathioprine.
- Chlorampiocell was found to be useful, some reports proved good results for post-neson with chloramosil.
Methotrexate: A dose of 7.5 mg per week and improved for patients who do not respond to steroid. The risk of cancerous malignancy in prolonged treatment should be taken into account when immunosuppressive drugs are used.
Adult unresponsive cases of systemic steroids may be treated with the following drugs:
Immuno-suppressive drugs:
Immunosuppressive agents may be used in adult patients who do not respond to corticosteroids but their use should be given to elective conditions. Immunosuppressants are not given to young patients with SLE.
- Azithoprene does not add anything to high doses of steroids in mild and moderate renal conditions, sudden withdrawal may cause relapse.
Cyclophosphamide may be more effective than immunosuppressive but more toxic than azathioprine.
Triad therapy: Prednisone azathyoprine and cyclophosphamide have no preference for treatment with prednisolone and azathioprine.
- Chlorampiocell was found to be useful, some reports proved good results for post-neson with chloramosil.
Methotrexate: A dose of 7.5 mg per week and improved for patients who do not respond to steroid. The risk of cancerous malignancy in prolonged treatment should be taken into account when immunosuppressive drugs are used.
Labels
skin diseases