Mal de meleda.. Diffusion of dermal parenchyma to dorsal surfaces of hands, feet, knees and elbows. Peeling and tingling Follow the redness of the palms and soles

Mal de meleda:
It is a rare syndrome that occurs in some families who marry relatives.
Secret features:
Skin manifestations:
The dermis is characterized by spreading to the dorsal surfaces of the hands, feet, knees, and elbows. This condition is associated with eczema, which is often secondary in vitro fertilization in early childhood.
Peeling and tingling The redness of the palms and soles usually follows, but sometimes appears as islands, extending to the dorsal surfaces in the form of gloves.
General features:
- Hyperhidrosis.
- Thickening of nails and nails.
- fusion of fingers.
- High palate bow.
- Use of the left hand (left).
Treatment:
- Solvent compounds such as salicylic acid alone or in combination with topical steroids (Locasalene or Diprosalic ointment) under the cover of solovin may produce good results.
Fluorouracil (Flurouracil ointment) ointment may give temporary improvement.
- Retinoids may have some value.
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