Darrier's disease.. A genetic disorder of abnormal keratosis, characterized by a constant rush of corneal papules especially on the sebaceous regions

Darrier's disease:
Is a hereditary disorder of abnormal calcification characterized by a constant rush of corneal papules especially on the sebaceous regions.
Clinical manifestations:
Pests mainly appear on the sebaceous areas of the face, scalp, forehead, nasal nasal folds, upper chest and back.
Dryer's disease is manifested in several clinical forms:
1 Hypertrophic type.
2 Vesiculobullous Fig.
3 Linear type.
- Primary skin lesions: are persistent fatty papillae crusted skin color, yellowish or structure may be mistakenly diagnosed as a count (young pills). Or seborrheic dermatitis. If the peeling shells are removed, the center holes of the funnel may sometimes appear.
- Scalp lesions: Scaly papules are very similar to sebum, but they have a distinctive sense of the spinal cord.
- Flexural surface lesions: mainly appear on the anal genital area, both areas of the mechanism. Pancreatic aggregation Non-regular warty plaques, lumps and papillae appear in the emotional surfaces and become sprouted and have a foul odor. Pests in the emotion surfaces may resemble dermatitis, fungal infections or psoriasis in the emotion surfaces.
- Palms and soles: may show hemorrhagic smears and grafted dotted or puncture accurate.
- Changes in the nails: distinctive whether shown red vertical bands or red and white ligaments in the form of V on the free edge of the nail.
- mucous membrane lesions: coagulated white papules or (Cobble Stone) on the palate, tongue, mucosa, pharynx, pharynx and pharynx wall similar to the recess in the visible and rectal vulva.
- Vaccine and viral infections: Dariere's disease appears to have increased susceptibility to simple contractile infections, chickenpox infections, impulsive eruption, Kapuzi rash and increased chronic purulent infection.
Pathological Anatomy:
It shows a distinctive form of dysplasia with ronds and spina bifida on the epidermis membrane.
Treatment:
- Some patients with light injuries do not need to treat only simple emollients and advised to expose areas affected by the sun.
- Patients with severe cases: the use of isotretinoids and isotretinoin usually given good results and good improvement.
- Isotretinate 1-2 mg / kg / day is another medication that is sometimes helpful.
- Co2 laser laser aspiration can be useful in severe warty conditions, especially in the hypertrophic species of the bacterium.
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