Which of the following sulfonylureas has the longest half- life:
- A) Tolbutamide
- B) Glibenclamide
- C) Tolzamide
- D) Chlorpropamide***
The sulfonylurea with the longest half-life is (D) Chlorpropamide.
Half-life is the time it takes for half of a drug to be eliminated from the body. Chlorpropamide has a half-life of 36-72 hours, which means that it takes 36-72 hours for half of the drug to be eliminated from the body. This makes it the longest-acting sulfonylurea.
The other sulfonylureas have shorter half-lives:
- Tolbutamide: 6-12 hours.
- Glibenclamide: 2-4 hours.
- Tolzamide: 3-6 hours.
This means that they are eliminated from the body more quickly and need to be taken more often.
It is important to note that the half-life of a drug can vary depending on the individual. Factors such as age, kidney function, and liver function can all affect how quickly a drug is eliminated from the body.
Therefore, the correct answer is D) Chlorpropamide.
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