Histamine is found in the human body in:
- a- The granules of mast cells in the blood
- b- The mucosal layer of the gi tract
- c- The hypothalamus
- d- A and b
- e- A, b and c***
The answer is (e) A, b and c.
Histamine is a chemical mediator that plays a role in a variety of physiological and pathophysiological processes, including inflammation, allergy, and immune response.
Histamine is stored in mast cells and basophils, which are types of white blood cells. Mast cells are found in tissues throughout the body, including the skin, lungs, and gastrointestinal tract. Basophils are found in the blood.
Effects:
When mast cells and basophils are activated, they release histamine, which binds to histamine receptors on nearby cells. This can cause a variety of effects, including:
- Vasodilation (widening of blood vessels).
- Increased vascular permeability (leakiness of blood vessels).
- Contraction of smooth muscles (such as the muscles in the airways).
- Stimulation of nerve endings.
Histamine also plays a role in the immune system by helping to recruit and activate other immune cells.
In addition to being stored in mast cells and basophils, histamine is also produced in the hypothalamus, a region of the brain that controls many important functions, including sleep, appetite, and temperature regulation.
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