What is the basis for current endodontic therapy of a periapical lesion

What is the basis for current endodontic therapy of a periapical lesion:
a. Due to rich collateral circulation system, the perpical area usually heals despite the condition of the root canal.
b. If the source of periapical irritation is removed, the potential for periapical healing is good. ***
c. Strong intracanal medications are required to sterilized the canal and periapical area to promote healing.
Periapical lesions, especially apical cyst, must be treated by surgical intervention.
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