The mechanism of action of NSAIDs for the treatment of rheumatoid arthritis.. Platelet assembly and balance and renal safety mucous infectious

The main mechanism and the expected effect of NSAIDs Is inhibition of the enzyme COX sichaelo oxygenase.

Enzyme sichaeloaoxeginaz converts arachidonic acid fat to Andobaroxadat, prostaglandins and Trumboxanat a certain way for the cell and these prostaglandins have a variety of physiological effects and multiple including the protection of the gastrointestinal tract and kidney balance and platelet collection and uterine smooth muscle contraction .... Etc.. And pretend widely in conditions associated with inflammation.

Initially, it was believed that the function of NSAIDs Is one type inhibition of the COX . However there are two types of COX two Cox1 And the COX2.

Thought to be the main mechanism that operates the COX 1 Is a vital enzyme important in the production of prostaglandins in maintaining renal function sound and preserve the integrity of and mucous balance.COX2 Practically undetectable in most tissues in physiological situations. However, the COX2 Provoked by inflammatory stimuli, including interleukin-1 (IL-1) Wall (TNF) . Specific increases in the levels of COX2 Found in places of inflammation in Diseases of the musculoskeletal system such as inflammatory rheumatic fever.

NSAIDs work Direct inhibition of COX1 And the COX2 And by preventing the enzyme site Alsichaelo oxygenase. The inhibition broostaglidinat reduces inflammation but simultaneously have additional effects on platelet collection and balance and renal infectious mucous safety. In addition, the NSAIDs Overlap with many other processes which can contribute to the effects of these processes. This includes production likotrinat and generate super oxide and liberate the enzyme lizausumal effects newtrovil and lymphocytes and cartilage metabolism.

Different NSAIDs Some extent and method of inhibiting COX1 And the COX2 And this often manifests for selective COX2: COX1 . This figure shows a clear difference depending on the enzyme or cell style originally used in the experiments. So it can not be held valid comparisons between different experiences.It is also unclear how to translate this ratio to the example of a medical. In saying that, we find that NSAIDs The inhibition of both COX1 And COX2 To the same degree.