Phosphorous lipids antibody syndrome.. Patients who are better with clinical features with quality and the presence of high levels of antibodies APA

Phosphorous lipids antibody syndrome Antiphospholipid antibodies (APA) syndrome

The patients who are better with clinical features with quality and the presence of high levels of antibodies APA Described that have antibody syndrome APA.

I studied this syndrome for the first time in the early fifties of the last century when women with long-term bleeding can not be cured, or suffer the case of excessive clotting ability Hypercoagulability And fetal loss occurs frequently.
And then described antibodies ACA And LA IgG) And IgM And (IgA Koddad earned her a special activity against lipid phosphorous bearing a negative charge,

Also believed to interfere with the installation of expanded vascular effective prostaglandin ProstaglandinAnd Albroostaschaelin Prostacyclin Through the cells lining the blood vessels Endothelial cells Exposed to coagulation and placental infarction Placental infarction Causing the inefficiency of the placenta and then pregnancy loss.

Independently adopt a link ACA On plasma protein is B 2 GP 1, That this protein is associated with negatively charged phosphorous Baahmyat and owns properties weak anticoagulant, at most through the inhibition of anticoagulant Toraltmas and effectiveness Anzim inhibition by Alkhtherin ProthrombinaseBlood plate.

He thus B 2 GP 1 As an adjunct Co factor In antibodies APA association, And it can be divided antibodiesACA To antibodies based on B 2 GP 1 And antibodies Garmatmdh. Characterized antibodies approved that have a direct link with the clinical features of the syndrome antibodies APA Compared to non-accredited.
The inhibition of natural anticoagulant by these antibodies may partially explain the tendency toward thrombosis in patients with antibody syndrome APA.

There was support for the idea of the differences between antibodies APA Where registered serum samples containing antibodies against B 2 GP 1 Often be positive in tests ACA While the sample containerLA And Garahawih antibodies ACA Shown to effectively link PAL B 2 GP 1.
The belief now is that there is a group of antibodies with a tendency toward diverse protein-lipid complexes phosphorescent Protein phospholipids, And this explanation, the antibodies of coagulation pattern lupus Lupus React with antibodies before Alkhtherin Prothrobmin Associated Baahmyat phosphorous or phosphorous lipid complexes with B 2 GP 1.
At which behave B 2 GP 1 As a catalyst and a protein is mandatory in the case of the presence of antibodies to ACA.

There are other proteins can sometimes work as catalysts mandatory and include Anksan - V (Rand et al., 1997) Annexin-V (AN-V) And protein C And S Anzim Lubricant phosphorusPhospholipase And placental anticoagulant protein Placental anticoagulant protein.

Although it is now clear that the APA antibodies Interact with lipids phosphorous, it is still there is no doubt about any of the determinants Almstddh interact with antibodies APA Wi catalysts for this reaction are required.